MEK Inhibitor CI-1040
Information
- Drug Name
- MEK Inhibitor CI-1040
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| skin melanoma |
PTEN p.Thr319Ter (p.T319*) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 ) PTEN p.Thr319Ter (p.T319*) ( ENST00000713839.1, ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 24504448 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| A 26-year old patient presented with vemurafenib r... | PTEN |
PTEN p.Thr319Ter (p.T319*) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 ) PTEN p.Thr319Ter (p.T319*) ( ENST00000713839.1, ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2 ) |
Sensitivity | true | CIViC Evidence | detail |